SOMETHING
Cardiovascular, ischemic stroke and CHD, myocardial infarction
TROMBOSES
Peripheral and cerebral veins, arteries
LOSS OF FOOD
Premature pregnancy, early miscarriage, fetoplacental insufficiency
gene F2
encodes the structure and formation of the protrombin protein
Prothrombin or coagulation factor II is one of the main components of the blood coagulation system.
As a result of its cleavage, thrombin, the base of the thrombus, is formed. This reaction is the first stage of blood clot formation.
A mutation in the F2 gene leads to increased gene expression, i.e., excessive prothrombin production. Subsequently, this leads to increased thrombosis.
F5 gene
encodes the TROMBIN PRODUCTION OF PROTROMBIN
A mutation in the gene makes the F5 factor resistant to the cleavage action of regulatory enzymes, resulting in hypercoagulability - increased blood clotting.
Mutation in the gene F5 and taking hormonal contraceptives mutually increase their effect on the clotting system, which leads to a significant increase in the risk of thrombosis when they are combined.
IN THE COMBINATION OF MUTATIONS in the F2 and F5 genes
the risk of thromboembolic complications during the use of hormonal contraceptives increases significantly. For this reason, experts believe that screening for the Leiden mutation and prothrombin gene mutation is necessary for ALL women taking hormonal contraceptives (or intending to take them).
