Predisposition to thrombophilia  Price 43 200 tenge

Hereditary thrombophilia (up to 80% of all thrombophilias) - predisposition to thrombosis and its complications as a result of genetic defects in the clotting, anticoagulant or fibrinolytic systems.

Indications for administration of the analysis:

thrombo1 thrombo12 thrombo13

  1. Increased tendency to thrombosis, arterial hypertension, myocardial infarction, CHD, ischemic stroke before 50 years of age.
  2. Cardiovascular diseases in relatives in the direct line, had myocardial infarction, ischemic stroke, deep vein thrombosis, pulmonary embolism under the age of 50 years.
  3. A history of pregnancy complications both in the patient and her relatives in the direct line (gestosis, preeclampsia, eclampsia, PONARP, ZVRP, stillbirth, early miscarriage, late miscarriage, premature birth, ante-natal fetal death in the anamnesis, etc.)

The genes under study:

  1. F2 - prothrombin gene
  2. F5 - acelerin gene, Leiden mutation
  3. F7 - proconvertin gene
  4. F13 - fibrin-stabilizing factor gene
  5. FBG - fibrinogen gene
  6. ITG A2 - platelet integrin gene
  7. ITG B3 - platelet integrin gene
  8. PAI 1 - plasminogen activator inhibitor gene

Application points of clotting system genes:

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Clinical manifestations of thrombophilia polymorphisms:

  1. Deep vein thrombosis of the lower extremities and other localizations
  2. CHD, myocardial infarction, ischemic stroke, TELA
  3. Complications of pregnancy (gestosis, eclampsia, PONARP, ZVRP, early and late miscarriages, fetoplacental insufficiency, antenatal fetal death, stillbirths, etc.)

Therapeutic and prophylactic recommendations:

After the presence of polymorphisms is established, the hemostasis system should be monitored. Take preventive measures to prevent thrombosis (taking anticoagulants, antiaggregants, etc.) during surgical interventions, pregnancy and other conditions provoking thrombosis.

Additional information:

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